Novo Nordisk Postdoctoral Research Fellow
I completed my PhD in Cardiac Physiology at the University of Otago (Dunedin, New Zealand) under the supervision of Dr Jeff Erickson, Dr Regis Lamberts and Associate Professor Fiona McDonald. During my PhD, I investigated the role of calcium calmodulin dependent protein kinase (CaMKII) in the progression of diabetic heart disease and provided evidence of a novel therapeutic potential for CaMKII inhibition to reverse impaired contractility and prevent heart failure progression in diabetic patients. I then moved onto my initial post-doctoral position at the University of Auckland (NZ) under the supervision of Dr Kim Mellor, further developing my research experience into cardiac metabolic dysregulation in diabetic cardiomyopathy.
I was awarded a Novo Nordisk Postdoctoral Research Fellowship to work with Professor David Ray in OCDEM and Dr Fang Zhang at the Novo Nordisk Research Centre Oxford, starting in January 2020. The focus of my fellowship is to investigate circadian regulation of liver energy metabolism in
diabetes. This project will capitalise on recent innovations which permit human liver organoids to be used as a translational model for diabetes and metabolic dysfunction. I will utilise high throughput ‘omics technology platforms, cell based assays and systems microscopy to allow entirely novel biology to be revealed and provide potential therapeutic advances.
Myocardial Energy Stress, Autophagy Induction, and Cardiomyocyte Functional Responses
Daniels LJ. et al, (2019), Antioxidants & Redox Signaling, 31, 472 - 486
Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats
Daniels LJ. et al, (2018), Cardiovascular Diabetology, 17
Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years
Pollock RD. et al, (2018), Aging Cell, 17, e12735 - e12735
The role of CaMKII in diabetic heart dysfunction
Daniels L. et al, (2015), Heart Failure Reviews, 20, 589 - 600