Sir Henry Wellcome Postdoctoral Fellow & Junior Research Fellow at Trinity College
- Mathematical modeller
Computational and experimental investigation of islet cells
Linford graduated with an MSc in Mathematics at the University of Bristol in 2009. He spent a year working at the Centre for Public Health (LJMU, Liverpool) and then began a PhD in Engineering Mathematics/Physiology and Pharmacology (with Prof Alan Champneys and Dr Tony Pickering - University of Bristol).
In November 2015 he began a postdoctoral position with Prof Patrik Rorsman and Prof Blanca Rodriguez investigating alpha-cell dysfunction in diabetes. He was awarded Sir Henry Wellcome fellowship in January 2017. During his fellowship he will use both computational and experimental techniques to understand which electrophysiological properties of alpha-cells are important for driving glucagon secretion, and how these may contribute to the impaired glucagon secretion observed in diabetes.
δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin.
Briant LJB. et al, (2018), J Physiol, 596, 197 - 215
Functional identification of islet cell types by electrophysiological fingerprinting.
Briant LJB. et al, (2017), J R Soc Interface, 14
Quantifying sympathetic neuro-haemodynamic transduction at rest in humans: insights into sex, ageing and blood pressure control
Briant LJB. et al, (2016), The Journal of Physiology, 594, 4753 - 4768
Unilateral Carotid Body Resection in Resistant Hypertension
Narkiewicz K. et al, (2016), JACC: Basic to Translational Science, 1, 313 - 324
Glucagon secretion from pancreatic α-cells.
Briant L. et al, (2016), Ups J Med Sci, 121, 113 - 119
Opto-genetic silencing of alpha-cells