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- Porcher Group: Molecular Dissection of Blood Cell Fate Determination Research Group
- Patient Group Research Group
I am a postdoctoral researcher both in Professor Roger Patient and Professor Catherine Porcher labs. I got my PhD degree in Biochemistry and Molecular Biology from Huazhong University of Science and Technology (HUST) in 2013, and after undertaking a postdoctoral position in HUST, I joined the Weatherall Institute of Molecular Medicine in Jan 2015.
My research focuses on identifying molecular pathways leading to haematopoietic stem cell (HSC) emergence during embryogenesis. VEGFA is a multifunctional signalling molecule that instructs successive stages of HSC development. We have already identified the transcriptional co-repressors ETV6 and ETO2 as key indirect regulators of Vegfa expression in the somites of Xenopus embryos at two distinct stages of blood development. In my project, I employ genomic and functional tools to study the transcriptional activities of ETV6 and ETO2 in order to identify the direct regulators of Vegfa expression in the somites. Ultimately, this study will help design protocols aiming at producing HSCs in vitro from pluripotent stem cells.
MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development.
Su Z. et al, (2014), Int J Biochem Cell Biol, 49, 53 - 63
Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish.
Li L. et al, (2014), Blood, 123, 501 - 508
Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis.
Chen D. et al, (2013), Hum Mol Genet, 22, 963 - 976
Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a mouse limb ischemia model.
Lu Q. et al, (2012), PLoS One, 7
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population.
Wang F. et al, (2011), Nat Genet, 43, 345 - 349