- Rorsman Group Research Group
JDRF Research Fellow
I joined the Oxford Centre for Diabetes, Endocrinology & Metabolism (OCDEM) as a JDRF-funded Research Fellow in 2016. My research interests are centred on the early development of autoimmunity in type 1 diabetes and the factors triggering progression to clinical disease. During my postdoctoral studies, I identified a major target of the autoimmune response in diabetes, a protein called tetraspanin-7. My current project aims to characterise the immune response to tetraspanin-7 in people with diabetes and to further our understanding of the role of this protein in the insulin-producing beta cell.
Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes.
McLaughlin KA. et al, (2016), Diabetes, 65, 1690 - 1698
Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients.
Catani M. et al, (2016), Diabetologia, 59, 294 - 298
Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.
Richardson CC. et al, (2016), Diabetologia, 59, 334 - 340
Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: Implications for determinant spreading.
McLaughlin KA. et al, (2015), Clin Immunol, 160, 226 - 236
Autoantibodies against Cytochrome P450 Side-Chain Cleavage Enzyme in Dogs (Canis lupus familiaris) Affected with Hypoadrenocorticism (Addison's Disease).
Boag AM. et al, (2015), PLoS One, 10