JDRF Research Fellow
I joined the Oxford Centre for Diabetes, Endocrinology & Metabolism (OCDEM) as a JDRF-funded Research Fellow in 2016. My research interests are centred on the early development of autoimmunity in type 1 diabetes and the factors triggering progression to clinical disease. During my postdoctoral studies, we identified a major target of the autoimmune response in diabetes, a protein called tetraspanin-7. My current project aims to characterise the immune response to tetraspanin-7 in people with diabetes and to further our understanding of the role of this protein in the insulin-producing beta cell.
High frequency of antibodies to IA-2, but lower frequencies of GAD65, ZnT8 and Tspan7 antibodies, in Asian patients with Type 1 diabetes
Tombs M. et al, (2018), Diabetic medicine, 35, 66 - 67
Autoantibody reactivity to tetraspanin-7 is directed to the cytoplasmic domains: Implications for immunoassay design
Mclaughlin KA. et al, (2018), Diabetic medicine, 35, 67 - 67
Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes.
McLaughlin KA. et al, (2016), Diabetes, 65, 1690 - 1698
Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients.
Catani M. et al, (2016), Diabetologia, 59, 294 - 298
Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.
Richardson CC. et al, (2016), Diabetologia, 59, 334 - 340