Kate Attfield
Junior Principal Investigator
Multiple sclerosis (MS) is the most common, chronic disabling neurological condition in young adults, afflicting more than 2.5 million people worldwide. Genome-wide association studies (GWAS) have identified more than 200 risk loci as contributing to disease susceptibility. However, the clinical utility of this data ultimately requires functional translation to identify cell types or pathways that are perturbed by these variants and to understand the role that exogenous triggers, which activate and drive the disease. Our research aims to unravel this complexity using an array of experimental platforms and to integrate and complement our findings with clinical data.
Recent publications
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The immunology of multiple sclerosis.
Journal article
Attfield KE. et al, (2022), Nat Rev Immunol
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Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis.
Journal article
Kaufmann M. et al, (2021), Med (N Y), 2, 296 - 312.e8
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Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient.
Journal article
Wurm H. et al, (2020), Mult Scler, 26, 1261 - 1264
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A novel neurodegenerative spectrum disorder in patients with MLKL deficiency.
Journal article
Faergeman SL. et al, (2020), Cell Death Dis, 11
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Structural and regulatory diversity shape HLA-C protein expression levels.
Journal article
Kaur G. et al, (2017), Nat Commun, 8