- Drakesmith Group: Iron and Immunity Research Group
I work as research assistant in Hal Drakesmith's group where I primarily consider hepcidin, the iron regulatory hormone, from a global health perspective. We have explored its potential for use as a diagnostic of iron deficiency in a number of environmentally and physiologically different populations. I also contribute to work within the Drakesmith lab that investigates hepcidin and iron status in the context of inflammation and infection.
I addition to this, I have supported the work of Dr Noémi Roy in her development of the Oxford Red Cell Panel, a diagnostic sequencing service within the John Radcliffe that screens for mutations linked to rare congenital anaemias. I continue to work in this area through exploration of potentially disease-causing variants that have been identified by whole genome sequencing.
I hold an MBioch from Oxford University, graduating in 2012 following a research project relating to localisation of mRNA in the neurons of fruit flies, and began work in the Drakesmith lab in 2014.
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Pasricha S-R. et al, (2017), Nat Commun, 8
Hepcidin detects iron deficiency in Sri Lankan adolescents with a high burden of hemoglobinopathy: A diagnostic test accuracy study.
Wray K. et al, (2017), Am J Hematol, 92, 196 - 203