BSc (Hons), DPhil
British Heart Foundation Centre for Research Excellence Intermediate Transition Fellow
My research is based around chemokine receptor regulation in inflammation and repair following myocardial infarction (MI) and how targeting this signalling may provide new approaches to modify post-MI injury and remodelling. By exploring the mechanisms that regulate leukocyte accumulation at inflammatory sites, we may be able to identify novel therapeutic targets in MI and heart failure.
I have previously investigated the role of a novel regulator of chemokine receptor signalling in leukocyte trafficking in atherosclerosis and aortic aneurysm formation and rupture. I have demonstrated that downstream G-protein regulation has a critical role in leukocyte chemotactic signalling, and modulates leukocyte accumulation in vascular inflammation (Patel et al, Nature Communications, 2015).
In addition to my research, I am actively involved in public engagement and science communication, taking part in Soapbox Science and Art, a national public outreach platform and a member of the European Society of Cardiology, Scientists of Tomorrow group which promotes cardiovascular scientists in training.
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Douglas G. et al, (2018), Cardiovasc Res, 114, 1385 - 1399
Effect of irradiation and bone marrow transplantation on angiotensin II-induced aortic inflammation in ApoE knockout mice.
Patel J. et al, (2018), Atherosclerosis, 276, 74 - 82
Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.
Chuaiphichai S. et al, (2018), Hypertension, 72, 128 - 138
Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.
Patel J. et al, (2018), Vascul Pharmacol
Novel aspects of chemokine receptor signalling in cardiovascular inflammation
Patel J. et al, (2018), CARDIOVASCULAR RESEARCH, 114, S70 - S70