BSc (Hons), DPhil
British Heart Foundation Centre for Research Excellence Intermediate Transition Fellow
My research is based around chemokine receptor regulation in inflammation and repair following myocardial infarction (MI) and how targeting this signalling may provide new approaches to modify post-MI injury and remodelling. By exploring the mechanisms that regulate leukocyte accumulation at inflammatory sites, we may be able to identify novel therapeutic targets in MI and heart failure.
I have previously investigated the role of a novel regulator of chemokine receptor signalling in leukocyte trafficking in atherosclerosis and aortic aneurysm formation and rupture. I have demonstrated that downstream G-protein regulation has a critical role in leukocyte chemotactic signalling, and modulates leukocyte accumulation in vascular inflammation (Patel et al, Nature Communications, 2015).
In addition to my research, I am actively involved in public engagement and science communication, taking part in Soapbox Science and Art, a national public outreach platform and a member of the European Society of Cardiology, Scientists of Tomorrow group which promotes cardiovascular scientists in training.
IL-10 reprogramming of metabolism in macrophages through mitophagy.
Patel J., (2017), Cardiovasc Res, 113, e40 - e41
Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE-/- Reporter Mouse-Brief Report.
McNeill E. et al, (2017), Arterioscler Thromb Vasc Biol, 37, 258 - 263
Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models.
Jones DP. et al, (2017), Mediators Inflamm, 2017
Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo.
McNeill E. et al, (2015), Sci Rep, 5
RGS-1 REGULATES LEUKOCYTE TRAFFICKING IN ATHEROSCLEROSIS AND AORTIC ANEURYSM FORMATION THROUGH ALTERED CHEMOKINE SIGNALLING
Patel J. et al, (2015), ATHEROSCLEROSIS, 241, E11 - E11