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Jordan Becker

Ruth L. Kirschstein NIH Postdoctoral Fellow

I joined the Chapman group after completing my PhD in 2016 and am interested in understanding how the breast and ovarian cancer susceptibility gene BRCA1 functions in the repair DNA breaks. My research aims to improve our understanding for why BRCA1 mutation carriers are predisposed to cancer, and identify characteristics of BRCA1-mutated cancers which are exploitable for treatment. This may also help us to understand why some tumours are drug resistant. To this end, my research has focused on the mechanisms by which BRCA1-BARD1 and 53BP1 interact with chromatin to influence DNA repair pathway choice. My PhD studies were completed in the laboratory of Prof. Anja-Katrin Bielinsky in the Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota, where I studied the role of PCNA in the replication stress response. I also obtained my BS in Genetics in 2010 at the University of Minnesota where I studied mechanisms that govern transposon mobility in Drosophila with Prof. Michael Simmons. 

Recent publications

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