- HIRO fellow
My research within the lab of Hal Drakesmith asks how iron availability impacts upon adaptive immunity. Genetic defects in immune cell iron uptake have been found to cause a human immunodeficiency syndrome, demonstrating the adaptive immune system's need for iron. We hypothesise that iron may become limiting for lymphocytes under conditions of physiological iron deficiency, resulting in an impaired adaptive immune response. Iron deficiency is the most prevalent micronutrient deficiency worldwide; understanding the nutritional requirements of immune responses might help us better implement vaccine regimes. I use a number of models to examine how iron restriction affects the development and effector function of lymphocytes.
I am based at the MRC Weatherall Institute of Molecular Medicine, within the MRC Human Immunology Unit (MRC HIU), and benefit from access to a number of core facilities: most significantly, the flow cytometry facility is of great importance to my work.
My DPhil was jointly funded by the RDM Scholars Programme and the Christopher Welch Scholarship in Biological Sciences. I have continued our investigations into the intersection of iron and immunity in a postdoctoral role supported by the HIRO (Human Iron Research in Oxford) fund.
The battle for iron in enteric infections.
Sousa Gerós A. et al, (2020), Immunology
Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-19.
Shah A. et al, (2020), Crit Care, 24
Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia.
Arezes J. et al, (2020), Blood, 135, 547 - 557
Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants.
Stoffel NU. et al, (2020), Front Immunol, 11
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.
Gooding S. et al, (2019), Nat Commun, 10