- Drakesmith Group: Iron and Immunity Research Group
My research focuses on understanding different aspects of iron metabolism in health and disease. I'm particularly interested in the regulation of the iron regulatory hormone hepcidin and how to use that knowledge to influence iron homeostasis in the context of diseases such as haemochromatosis and anaemia.
I hold a BSc (2009) and a MSc (2011) in Biochemistry, and a PhD (2015) in Basic and Applied Biology from the University of Porto, Portugal. As a PhD student, I worked at the University of California, Los Angeles under the supervision of Tomas Ganz and Elizabeta Nemeth, where I described the critical role of hepcidin in the host defense against the pathogen Vibrio vulnificus.
Since 2015 I have been working as a Postdoctoral researcher with Professor Hal Drakesmith at the MRC Weatherall Institute of Molecular Medicine, University of Oxford.
Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.
Stefanova D. et al, (2017), Blood, 130, 245 - 257
Hepcidin and iron disorders: new biology and clinical approaches.
Arezes J. and Nemeth E., (2015), Int J Lab Hematol, 37 Suppl 1, 92 - 98
Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus.
Arezes J. et al, (2015), Cell Host Microbe, 17, 47 - 57
Physiological implications of NTBI uptake by T lymphocytes.
Pinto JP. et al, (2014), Front Pharmacol, 5
Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species.
Arezes J. et al, (2013), PLoS One, 8