My research focuses on understanding different aspects of iron metabolism in health and disease. I'm particularly interested in the regulation of the iron regulatory hormone hepcidin and how to use that knowledge to influence iron homeostasis in the context of diseases such as haemochromatosis and anaemia.
I hold a BSc (2009) and a MSc (2011) in Biochemistry, and a PhD (2015) in Basic and Applied Biology from the University of Porto, Portugal. As a PhD student, I worked at the University of California, Los Angeles under the supervision of Tomas Ganz and Elizabeta Nemeth, where I described the critical role of hepcidin in the host defense against the pathogen Vibrio vulnificus.
Since 2015 I have been working as a Postdoctoral researcher with Professor Hal Drakesmith at the MRC Weatherall Institute of Molecular Medicine, University of Oxford.
Erythroferrone inhibits the induction of hepcidin by BMP6.
Arezes J. et al, (2018), Blood
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Pasricha S-R. et al, (2017), Nat commun, 8
THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE GLOBULAR DOMAIN OF MOUSE ERFE
McHugh K. et al, (2017)
HEPCIDIN MEDIATES HOST DEFENSE AGAINST GRAM-NEGATIVE PATHOGENS BY CONTROLLING NON-TRANSFERRIN-BOUND IRON
Stefanova D. et al, (2017), American journal of hematology, 92, E207 - E207
Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.
Stefanova D. et al, (2017), Blood, 130, 245 - 257