Sodium MRI (23Na-MRI) has been used to non-invasively quantify tissue sodium but has been limited by low spatial resolution. Here we demonstrate for the first time that high resolution 23Na-MRI reveals the spatial heterogeneity of sodium concentration within a multiple sclerosis (MS) lesion. A patient with treatment-naïve relapsing-remitting MS and a ring-enhancing lesion was imaged using 23Na-MRI. The periphery of the lesion demonstrated an elevated total sodium content compared to the normal appearing white and grey matter (p<0.01), as well as a heterogeneous distribution of both the total tissue sodium concentration and the intracellular-weighted sodium concentration.
Journal article
2018-04-15T00:00:00+00:00
387
111 - 114
3
(23)Na, 3-tesla, Extracellular sodium, High-resolution, Intracellular sodium, Multiple sclerosis, Adult, Analysis of Variance, Brain, Disability Evaluation, Female, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Multiple Sclerosis, Sodium, Sodium Radioisotopes