My DPhil project focuses on investigating gene therapy for surfactant protein B deficiency using AAV vectors. Surfactant protein B deficiency is an autosomal recessive genetic disorder which is fatal during the first months of life. Conventional therapy has been shown to be ineffective in those affected. Surfactant protein B plays a major role in surfactant homeostasis. Surfactant is a thin film that covers the gas exchange surface in the lung and prevents the lung from collapsing.
Before joining the Gene Medicine group in October 2017, I completed my Bachelor's and Master's degree in Biochemistry at Ludwig-Maximilians-Univerity Munich. During my Master thesis, I investigated immunotherapy to target HBV-associated hepatocellular carcinoma.