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Geoffrey Denwood

BSc (Hons), PhD


Postdoctoral Research Assistant

I completed my BSc (Hons) in Molecular Genetics at the University of Dundee and after organising summer vacation research projects in the laboratories of Prof Michael Ashford and Prof Rory McCrimmon, I went on to complete my PhD research under their supervision investigating the regulation of hypothalamic glucose-sensing neurons by cytokines such as Interleukin-6. I utilised electrophysiology and a variety of molecular biology and biochemistry techniques to investigate electrical activity and metabolism in these neurons.   

In January 2017 I came to OCDEM to undertake postdoctoral research under the supervision of Dr Quan Zhang. My current research focuses on understanding the cellular and molecular control of pancreatic hormone secretion, with a particular interest in how glucose and other nutrients regulate glucagon secretion from alpha cells, a topic which is still debated and incompletely understood. I exploit electrophysiology, hormone secretion and imaging techniques to interrogate both the intrinsic and paracrine mechanisms underpinning glucagon secretion from alpha cells. We anticipate our research will lead to the identification of novel therapeutic targets for the treatment of diabetes and metabolic disease.

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