Hypercholesterolaemia promotes epigenetic memory in hematopoietic stem cells that persists after lipid lowering and causes systemic immunometabolic dysfunction mediated by macrophage metabolic reprogramming

Purvis GSD., Jiang J., Hiron TK., Simoglou Karali C., Baxter M., Li R., Vijjhalwar R., Diotallevi M., Draycott SAV., Chuaiphichai S., Douglas G., McNeill E., Mead AJ., Greaves DR., O’Callaghan CA., Channon KM.

DOI

10.1101/2025.09.15.676283

Type

Preprint

Publication Date

2025-09-18T00:00:00+00:00

Permalink More information Close