My first exposure to research was at University of Chieti (Italy) in 2006. During my PhD I was mainly interested in oxidative stress and its relationship with cancer cell proliferation.
In 2014 I had the opportunity to join, as a Marie Curie Postdoctoral fellow, the Department of Cardiovascular Medicine, Radcliffe Department of Medicine. This appointment provided and excellent opportunity to engage in oxidative stress research, where I could apply my skills as molecular biologist to understand the basics of atherosclerosis and the crosstalk between adipose tissue and vascular wall.
I am currently working as Postdoctoral Research Associated Fellow in Prof Antoniades' group at University of Oxford, in a research programme funded by the British Heart Foundation. In this particular project I focus on the relationship between adipose tissue and the vascular wall. I am studying the molecular mechanisms through which perivascular adipose tissue and vascular smooth muscle cells communicate with each other. Using ex vivo models of human vessels, as well as human vascular cells and adipocytes, my research focuses on the role of a wide range of molecules serving as a link to mediate perivascular adipose tissue and vascular cells communication. I am also interested in discovering novel therapeutic strategies targeting vascular and myocardial redox signaling.
Detecting human coronary inflammation by imaging perivascular fat
Antonopoulos AA. et al, (2017), Science Translational Medicine
Predictive value of telomere length on outcome following acute myocardial infarction: Evidence for contrasting effects of vascular vs. blood oxidative stress
Margaritis M. et al, (2017), European Heart Journal
Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling.
Antonopoulos AS. et al, (2016), Circ Res, 118, 842 - 855
Telomere length predicts clinical outcomes post-revascularization procedures: its role as a novel biomarker of systemic oxidative stress and cardiovascular ageing
Margaritis M. et al, (2015), EUROPEAN HEART JOURNAL, 36, 328 - 328
Exploring the obesity paradox in secondary prevention: a new biological role of femoral adipose tissue in humans
Antonopoulos A. et al, (2015), EUROPEAN HEART JOURNAL, 36, 441 - 441