My first exposure to research was at University of Chieti (Italy) in 2006. During my PhD I was mainly interested in oxidative stress and its relationship with cancer cell proliferation.
In 2014 I had the opportunity to join, as a Marie Curie Postdoctoral fellow, the Department of Cardiovascular Medicine, Radcliffe Department of Medicine. This appointment provided and excellent opportunity to engage in oxidative stress research, where I could apply my skills as molecular biologist to understand the basics of atherosclerosis and the crosstalk between adipose tissue and vascular wall.
I am currently working as Postdoctoral Research Associated Fellow in Prof Antoniades' group at University of Oxford, in a research programme funded by the British Heart Foundation. In this particular project I focus on the relationship between adipose tissue and the vascular wall. I am studying the molecular mechanisms through which perivascular adipose tissue and vascular smooth muscle cells communicate with each other. Using ex vivo models of human vessels, as well as human vascular cells and adipocytes, my research focuses on the role of a wide range of molecules serving as a link to mediate perivascular adipose tissue and vascular cells communication. I am also interested in discovering novel therapeutic strategies targeting vascular and myocardial redox signaling.
Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress.
Margaritis M. et al, (2017), Eur Heart J, 38, 3094 - 3104
Perivascular adipose tissue as an endocrine organ: the role of statins.
Sanna F. et al, (2017), Curr Pharm Des
Statins and oxidative stress in the cardiovascular system.
Margaritis M. et al, (2017), Curr Pharm Des
Detecting human coronary inflammation by imaging perivascular fat.
Antonopoulos AS. et al, (2017), Sci Transl Med, 9
Novel insights into the effects of insulin-like growth factor 1 and endothelin signalling on vascular redox state in patients with type 2 diabetes
Akoumianakis I. et al, (2016), DIABETOLOGIA, 59, S507 - S508