Emmanouela Repapi
MSc; PhD
UKRI Rutherford Fund Fellow
Novel methods for the integration of high dimensional single cell proteomic and RNA data to understand cell populations in development and disease.
Emmanouela is a UKRI Rutherford Fund Fellow working to develop a methodology for the integration of data from single cell RNA-Seq technologies with mass spectrometry (CyTOF) data in order to study cell heterogeneity and differentiation. The project’s aims include the use of machine learning techniques for the analysis along with novel visualisation tools to improve interpretability of the data.
Prior to her fellowship, Emmanouela worked for the Computational Biology Research Group providing advice and expertise on statistical analyses for a variety of projects of the WIMM, focusing on the analysis of all types of RNA Sequencing data and teaching the RNA-Seq course along with Nicki Gray. She completed her DPhil at the Ludwig Institute for Cancer Research at the University of Oxford working on the identification and analysis of single nucleotide polymorphisms (SNPs) that affect cancer in humans. She was involved in numerous projects, working with clinical and genetic data of different types of cancer including chronic lymphocytic leukemia, melanoma and pancreatic cancer. Prior to her PhD, she worked as a training fellow in Genetic Epidemiology at the University of Leicester conducting a meta-analysis of Genome Wide Association Studies (GWAS) for pulmonary function. Her first degree was in Applied Mathematics at the National Technical University of Athens before completing an MSc in Applied Statistics at the University of Oxford.
Recent publications
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The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin.
Journal article
Truch J. et al, (2022), Nat Commun, 13
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IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent.
Journal article
Hardman CS. et al, (2021), Sci Immunol, 6
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A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Working paper
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None. et al, (2021)
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BET inhibition disrupts transcription but retains enhancer-promoter contact.
Journal article
Crump NT. et al, (2021), Nat Commun, 12
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Single-cell atlas of colonic CD8+ T cells in ulcerative colitis.
Journal article
Corridoni D. et al, (2020), Nat Med, 26, 1480 - 1490
ORCID
0000-0001-8085-0731