My current research focuses on the developmental biology of hematopoietic stem and progenitor cells (HSPCs). I am interested in the role of micro-environmental (or niche) factors, such as cytokines and blood flow, in HSPCs emergence and expansion in the mouse embryo. I am also particularly interested in the biology of hematopoietic progenitors appearing before hematopoietic stem cells.
This work is important because building a roadmap of hematopoiesis in the embryo will help improving the generation of HSPCs in vitro for regenerative medicine. I use a range of techniques including confocal whole mount immunofluorescence, multicolour flow cytometry, primary cell cultures and RNA sequencing.
I have completed my Ph.D. program at the University of Milan-Bicocca (Milan, Italy) in 2011. I moved to Oxford in December 2012.