My current research focuses on the developmental biology of hematopoietic stem and progenitor cells (HSPCs). I am interested in the role of micro-environmental (or niche) factors, such as cytokines and blood flow, in HSPCs emergence and expansion in the mouse embryo. I am also particularly interested in the biology of hematopoietic progenitors appearing before hematopoietic stem cells.
This work is important because building a roadmap of hematopoiesis in the embryo will help improving the generation of HSPCs in vitro for regenerative medicine. I use a range of techniques including confocal whole mount immunofluorescence, multicolour flow cytometry, primary cell cultures and RNA sequencing.
I have completed my Ph.D. program at the University of Milan-Bicocca (Milan, Italy) in 2011. I moved to Oxford in December 2012.
Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.
Azzoni E. et al, (2018), Embo rep, 19
Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.
Neo WH. et al, (2018), Blood, 131, 2223 - 2234
Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.
Luis TC. et al, (2016), Nat immunol, 17, 1424 - 1435
EMBRYONIC THYMOPOIESIS IS INITIATED BY AN IMMUNE-RESTRICTED LYMPHO-MYELOID PROGENITOR INDEPENDENTLY OF NOTCH SIGNALING
Luis TC. et al, (2016), Experimental hematology, 44, S65 - S65
PATHWAYS REGULATING THE ENDOTHELIAL-TO-HEMATOPOIETIC TRANSITION
de Bruijn M. et al, (2016), Experimental hematology, 44, S29 - S29