Dominic Waithe
BSc. MSc. PhD.
UKRI Innovation Fellow
Developing dynamic imaging and analysis methods.
Dr Dominic Waithe
Dominic is a UKRI Innovation Fellow with the MRC Centre for Computational Biology and the Wolfson Imaging Centre at the MRC Weatherall Institute of Molecular Medicine, University of Oxford, UK. In his current position he applies biophysics, machine learning and computer vision techniques to develop novel microscopy based dynamic acquisition pipelines. His background includes degrees from University College London in biotechnology, molecular neuroscience and computer science. He has performed post-doctorate research in the field of molecular neuroscience as well as in applied microscopy and image analysis. Prior to his present position, he worked for 4 years in the Wolfson Imaging Centre Oxford (https://www.imm.ox.ac.uk/research/facilities/wolfson-imaging-centre) working closely with the group of Christian Eggeling (http://www.nano-immunology.org/), developing novel bioimage analysis and correlation techniques.
Dominic regularly teaches image processing and analysis courses and co-organises image analysis lectures for the Doctoral Training Centre, Oxford (http://www.dtc.ox.ac.uk/).
Dominic is the acting chair of the Image Analysis Focused Interest Group of the Royal Microscopical Society (http://iafig-rms.org/) and is also on the UK management team for Neubias (http://eubias.org/NEUBIAS/).
Key publications
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Optimized processing and analysis of conventional confocal microscopy generated scanning FCS data.
Journal article
Waithe D. et al, (2018), Methods, 140-141, 62 - 73
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FoCuS-point: software for STED fluorescence correlation and time-gated single photon counting.
Journal article
Waithe D. et al, (2016), Bioinformatics, 32, 958 - 960
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3-D density kernel estimation for counting in microscopy image volumes using 3-D image filters and random decision trees
Conference paper
Waithe D. et al, (2016), Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 9913 LNCS, 244 - 255
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QuantiFly: Robust Trainable Software for Automated Drosophila Egg Counting.
Journal article
Waithe D. et al, (2015), PLoS One, 10
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Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.
Journal article
Waithe D. et al, (2011), J Biol Chem, 286, 9598 - 9611
Recent publications
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Object detection networks and augmented reality for cellular detection in fluorescence microscopy.
Journal article
Waithe D. et al, (2020), J Cell Biol, 219
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Hypoxia regulates endogenous double-stranded RNA production via reduced mitochondrial DNA transcription
Journal article
Arnaiz E. et al, (2020)
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CytoCensus, mapping cell identity and division in tissues and organs using machine learning.
Journal article
Hailstone M. et al, (2020), Elife, 9
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Ligand-dependent downregulation of MR1 cell surface expression
Journal article
Awad W. et al, (2020), Proceedings of the National Academy of Sciences of USA
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Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure.
Journal article
Rodríguez Cruz PM. et al, (2020), Hum Mutat, 41, 619 - 631