Senior Postdoctoral Researcher
I studied medicine at the Medical University in Gdansk, Poland and qualified as an MD in 2003. I subsequently moved to the UK and undertook a PhD programme in Infection and Immunity at the University of Liverpool, where I investigated the role of Natural Killer T (NKT) cells in rheumatoid arthritis. I came to Oxford to join MRC Human Immunology Unit at the Weatherall Institute of Molecular Medicine in 2009. I am pleased to have been working as a postdoctoral immunologist/senior postdoctoral immunologist in the Cutaneous Immunology Group of Professor Graham Ogg since.
I am interested in the basic mechanisms of allergic inflammation with relevance to atopic dermatitis (AD). I specifically focus on the epidermal barrier formation and function as well as communication between the non-immune component of the skin (keratinocytes) and the cells of the immune system. My previous work increased our understanding of how the AD pathology (persistent inflammatory state and aberrant keratinocyte differentiation) affects the function of the skin barrier. I also determined how keratinocyte-mediated responses of T cells to environmental allergens change in the context of AD. In a recent collaboration with the Nanoimmunology group, using powerful high- and super-resolution microscopy techniques, we also discovered a fundamental mechanism governing epidermal stratification and cornification during the formation of functional epidermal barrier. Currently I am interested in long distance communication in the skin and how this affects inflammation and allergen-specific T cell reactivity. Presently these studies investigate basic immunological mechanisms, but with a focus on translational angle in the future I hope my work will also contribute to the availability of novel therapeutic options for allergic patients.
Deficiency of filaggrin regulates endogenous cysteine protease activity, leading to impaired skin barrier function.
Wang XW. et al, (2017), Clin Exp Dermatol, 42, 622 - 631
Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.
Cheung KL. et al, (2016), J Exp Med, 213, 2399 - 2412
Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.
Jarrett R. et al, (2016), Sci Transl Med, 8
Platelet activating factor contributes to vascular leak in acute dengue infection
Jeewandara KC. et al, (2015), ALLERGY, 70, 138 - 138
Platelet activating factor contributes to vascular leak in acute dengue infection.
Jeewandara C. et al, (2015), PLoS Negl Trop Dis, 9