PhD; MRes; BSc
My research focusses on a membrane protein called Interferon-induced transmembrane protein 3 (IFITM3) which is important in the restriction and control of several viruses, including Influenza virus, Dengue virus, Hanta virus, Hepatitis C virus and Human immunodeficiency virus (HIV). The mechanism for viral restriction by IFITM3 is unknown but it is thought that IFITM3 can prevent the release of the viral genome from the endocytic compartment into the cytosol, a necessary step for viral replication. A mutation in the DNA of IFITM3 can lead to faster progression to AIDS or liver cirrhosis in HIV and Hepatitis C infections, respectively, as well as increasing the severity of influenza in patients with this mutation. This is despite the fact that this single nucleotide polymorphism (SNP), rs12252, has no effect on the protein sequence of IFITM3.
I am working to characterise IFITM3 further by confirming its location within cells and determining whether this can be altered due to interferon concentration or type, as well as following infection with influenza or HIV virus. With more knowledge of the IFITM3 protein we hope to learn how it functions in viral restriction and why the SNP rs12252 has such a large influence on the severity of viral infections.
Prior to joing the University of Oxford, I graduated from the University of Bristol with a BSc in Cancer Biology & Immunology, before completing an integrated PhD (MRes and PhD combined) in Cancer sciences at the University of Southampton. I am now a post-doctoral scientist in Prof Tao Dong's lab group, within the MRC Human Immunology Unit. In addition to my research I like to take an active role in public engagement and inspiring the next generation of young scientists. Within my role as a STEM ambassador I regularly speak with school children about life as a scientist as well as organising and taking part in activities to get the public excited about research.
Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection.
Makvandi-Nejad S. et al, (2018), J Infect Dis, 217, 257 - 262
High Level Antibody Response to Pandemic Influenza H1N1/09 Virus Is Associated With Interferon-Induced Transmembrane Protein-3 rs12252-CC in Young Adults.
Qin L. et al, (2018), Front Cell Infect Microbiol, 8
Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia.
Barker R. et al, (2014), Brain, 137, 1524 - 1532