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Claire Duff

BSc (Hons)


DPhil Student

I am a postgraduate MRC Industrial CASE DPhil student, based at both OCDEM and the Wellcome Trust Centre for Human Genetics. My DPhil is supervised by Prof Anna Gloyn and Benoit Hastoy at OCDEM and by Dr Christian Honore and Dr Mattias Hansson at Novo Nordisk, where I spent six weeks during my DPhil project.

My research centres on understanding mechanisms of beta-cell dysfunction using genome engineering in patient-derived induced pluripotent stem cells, alongside a complementary overexpression model in the EndoC-BH1 cell line. I have utilised monogenic forms of diabetes caused by mutations in the insulin and HNF1A genes as a model to further understand how beta cell dysfunction in diabetes occurs.

Recent publications

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