I am a postgraduate MRC Industrial CASE DPhil student, based at both OCDEM and the Wellcome Trust Centre for Human Genetics. My DPhil is supervised by Prof Anna Gloyn and Benoit Hastoy at OCDEM and by Dr Christian Honore and Dr Mattias Hansson at Novo Nordisk, where I spent six weeks during my DPhil project.
My research centres on understanding mechanisms of beta-cell dysfunction using genome engineering in patient-derived induced pluripotent stem cells, alongside a complementary overexpression model in the EndoC-BH1 cell line. I have utilised monogenic forms of diabetes caused by mutations in the insulin and HNF1A genes as a model to further understand how beta cell dysfunction in diabetes occurs.
Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples
Christakoudi S. et al, (2019), EBioMedicine, 41, 571 - 583
Genetic predictors of long-term graft function in kidney and pancreas transplant patients.
Duff CE. and Simmonds MJ., (2017), Brief Funct Genomics, 16, 228 - 237
Caveolin-1 single-nucleotide polymorphism and arterial stiffness in non-dialysis chronic kidney disease.
Chand S. et al, (2016), Nephrol Dial Transplant, 31, 1140 - 1144
Impact of < i > HMOX1 </i > Genetic Variation in Pancreas Transplant Recipients On Long-Term Graft Outcome
Duff C. et al, (2015), AMERICAN JOURNAL OF TRANSPLANTATION, 15
Influence of pancreas transplant recipient CTLA-4 genotype on long-term graft function
Duff CE. et al, (2015), DIABETIC MEDICINE, 32, 86 - 87