DPHIL SUPERVISOR PROFILE
Professor of Molecular Immunology
We apply and optimize advanced optical microscopy techniques such as super-resolution STED microscopy for deciphering molecular dynamics in so far unprecedented ways. Our main focus is molecular plasma membrane organization, especially following immune responses. For further information see: www.nano-immunology.org.
Prof Eggeling holds a PhD in Physics from the University of Göttingen, where he optimized single-molecule detection. From 2000 to 2003 he was a research scientist at Evotec, Hamburg, developing advanced fluorescence microscopy techniques for high-throughput drug screening. In 2003, Christian joined the MPI of Biophysical Chemistry, Göttingen as a senior scientist in the department of Professor Stefan Hell (2014 Nobel Laureate in Chemistry). Here, he was focused on the field of optical super-resolution microscopy, specifically the biological applicability of stimulated emission depletion (STED) microscopy.
Since 2012, Christian has been a principal investigator in the MRC Human Immunology Unit and the scientific director of the Wolfson Imaging Centre at the MRC Weatherall Institute of Molecular Medicine, University of Oxford. From 2014, as a Professor of Molecular Immunology, Christian's research has been focused on advanced microscopy for the investigation of immune cells and cellular plasma membrane organization.
Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions.
Carravilla P. et al, (2019), Nat Commun, 10
CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity
Felce JH. et al, (2018), Science Signaling, 11, eaat0756 - eaat0756
The 2018 correlative microscopy techniques roadmap
Ando T. et al, (2018), JOURNAL OF PHYSICS D-APPLIED PHYSICS, 51
How to minimize dye-induced perturbations while studying biomembrane structure and dynamics: PEG linkers as a rational alternative.
Mobarak E. et al, (2018), Biochim Biophys Acta Biomembr, 1860, 2436 - 2445
Lipid Composition but Not Curvature Is the Determinant Factor for the Low Molecular Mobility Observed on the Membrane of Virus-Like Vesicles.
Urbančič I. et al, (2018), Viruses, 10