I am working as a Research Assistant in the Rehwinkel group. I provide ad-hoc help to other members of the group to advance their different projects. I also make sure the lab runs smoothly by carrying out different duties, including organisational and technical support, in vivo models and other lab management tasks.
I did my undergraduate and graduate studies at the University of Pisa, Italy, where I had the possibility to work on different projects during my academic pathway. During a post-graduate fellowship I became deeply interested in the complicated interactions happening between the host and the pathogen during an infection. Following this passion, I decided to join the Rehwinkel group, which focuses mainly on the molecular biology of activation and regulation of innate immune receptors that survey the cytosol upon infection. Using a wide variety of virus infection models including influenza A virus, HIV and other retroviruses, flaviviruses such as Zika virus, and herpesviruses, we are hoping to answer important questions in the field and to better understand the links with autoimmune diseases and cancer.
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
Maelfait J. et al, (2016), Cell Rep, 16, 1492 - 1501
Gene editing of DNAH11 restores normal cilia motility in primary ciliary dyskinesia.
Lai M. et al, (2016), J Med Genet, 53, 242 - 249
Human Wharton's jelly-derived mesenchymal stromal cells engineered to secrete Epstein-Barr virus interleukin-10 show enhanced immunosuppressive properties.
Quaranta P. et al, (2016), Cytotherapy, 18, 205 - 218