Society For Endocrinology Early Career Grant www.endocrinology.org
Oxfordshire Health Services Research Committee (OHSRC) Research Grant
MBBS BSc MRCP DPhil
Academic Clinical Lecturer, Honorary Specialist Registrar in Diabetes and Endocrinology
I am a postdoctoral researcher within the Metabolic Research Group at the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM). My research interest is the relationship between iron metabolism and body fat distribution.
Obesity is common and is a risk factor for diseases like type 2 diabetes and heart disease. Where a person stores their fat is just as important as how much fat they have. Storing fat around the middle is a strong risk factor for type 2 diabetes and heart disease, whilst storing fat on the lower body is protective. I am interested in what causes different people to store fat in different places. Erythroferrone is a protein that controls the absorption of dietary iron from the gut. I am exploring whether it also regulates body fat distribution.
Before I started this project I completed a DPhil within the same group. I investigated small molecules called microRNA and how they affect body fat distribution in humans. Alongside my research I work as a doctor in Diabetes and Endocrinology.
MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition.
Hilton C. et al, (2019), EBioMedicine, 44, 467 - 475
Hormone therapy should not be prescribed for primary prevention of chronic medical conditions in asymptomatic postmenopausal women.
Hilton C. and Boardman H., (2018), BMJ Evid Based Med, 23, 231 - 232
A cellular model for the investigation of depot specific human adipocyte biology.
Todorčević M. et al, (2017), Adipocyte, 6, 40 - 55
American Diabetes Association meeting report.
Hilton C. and Beer NL., (2016), J Clin Transl Endocrinol, 5, 53 - 54
Effect of microRNA-196a on regulation of body-fat distribution in man
Hilton C. et al, (2014), LANCET, 383, 56 - 56