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Caroline Gorvin


Postdoctoral Researcher

My research is focussed, at a general level, on trafficking and signalling of membrane proteins, and how impairments in their signalling pathways contribute to endocrine disorders. In particular, my research concentrates on the role of the Calcium-Sensing Receptor (CaSR) and components of its signalling pathway in calcium homeostasis. The CaSR is a class C G-protein coupled receptor (GPCR), mutations of which are associated with both hyper- and hypocalcemia. Mutations in two proteins that regulate CaSR, Gα11, which regulates CaSR signalling, and the adaptor protein-2 sigma subunit, AP2σ, which is critical for clathrin-mediated endocytosis, also cause disorders of calcium homeostasis. My work on the CaSR focusses on the mechanisms by which these mutations affect CaSR signalling and trafficking. 

 

My research is largely cell based, and involves a range of cell types including engineered stable cell-lines of specific mutations, gene-edited cell-lines with deletion of components of signalling pathways, and immortalized patient cells. To assess cell function, I combine imaging techniques including TIRF microscopy and single cell microfluorimetry, with plate based assays such as AlphaScreen phosphorylation and luciferase reporter assays. I have received national and international prizes for my research, and I’m very happy to collaborate with people across disciplines.

 

Research Funding: 

Goodger and Schorstein Scholarship for Postdoctoral Researchers in Medical Sciences

Society for Endocrinology Early Career Grant

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Key Publications

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Recent Publications

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