Senior Postdoctoral Fellow
I did my undergraduate in Organic Chemistry at the University of Rouen and obtained my PhD on permanganate oxidative cyclisation under the supervision of Dr R.C.D. Brown at the University of Southampton.
I then undertook two consecutive post-doctoral positions with Professor T.J. Donohoe on tethered aminohydroxylation methodology and with Dr J.M. Brown, FRS on resolution of stereolabile biaryl ligands using novel chiral dienes at the Chemistry Research Laboratory, Oxford.
I previously worked as a senior post-doctoral researcher in the Angela Russell group and with Professor S.G. Davies, at Oxford. I had the opportunity to work on a range of medicinal chemistry projects from synthesizing novel PIM kinase inhibitors used in the treatment of cancer, to anti-viral agents against Hepatitis C virus as well as novel compounds used in the proliferation of stem cells and their selective differentiation.
I am currently working on a project under the supervision of Professor Terry Rabbitts, funded by Bloodwise (Leukaemia and Lymphoma Research) on the synthesis of novel small molecules, used in protein-protein interaction to prevent, proliferation of cancer cells via a fragment-based approach and in silico methods using inhibition antibody fragments as structured templates.
Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
Cruz-Migoni A. et al, (2019), Proc Natl Acad Sci U S A, 116, 2545 - 2550