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Barnabas Williams

BSc (Hons), MRes

DPhil Student

I am a postgraduate student, working under the supervision of Prof Deborah Gill and Prof Steve Hyde in the Gene Medicine Research Group.

My research focuses on the enhancement of lentiviral vector production through altered host-virus interactions.  Lentiviral vectors can efficiently deliver genetic cargo to a wide variety of non-dividing cells making them strong candidates for clinical development. They have been used in numerous gene therapy clinical trials to treat diseases such as Parkinson's disease and Acute Lymphoblastic Leukaemia. Lentiviral vectors are, however, expensive to manufacture and suffer from lower titres than adeno-associated viruses (AAV) vectors hampering clinical development. My research aims to improve lentiviral vector production by altering host factors within production cells therefore making gene therapy with lentiviral vectors more feasible.

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