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Arthur Disegna


Senior Hulme Scholar

I obtained my medical degree from the University of Brasília, in 2019, during which I conducted research on artificial intelligence to diagnose complications of pituitary disorders. As a doctor, I worked as an Intensive Care Clinical Fellow in Brazilian private hospitals throughout the pandemic before moving to Oxford for my DPhil (PhD).

The theme of my research is Traumatic Brain Injury (TBI). Specifically, I am looking at how blood abnormalities triggered by the injury worsen the clinical course of patients.

My research group employs locally developed advanced magnetic resonance techniques to identify foci of vascular injury and intra-cerebral bleeding in vivo with an unprecedentedly high resolution. We are taking these measurements along with novel and established neuronal and endothelial injury biomarkers, including exosomes.

I am also running a sub-study within a UK-wide clinical trial that will build an extensive repository of brain imaging and blood samples from patients with TBI. This will facilitate mechanistic research on the haematological and immune bases of brain oedema and haemorrhage in TBI through artificial intelligence-powered analyses of brain scans.

I am a member of Brasenose College (University of Oxford), where I also serve as a Junior Dean, and of Oxford's Global Leadership Initiative (GLI). External to Oxford, I am a fellow of the Líderes program, a private scholarship aimed at Brazilian nationals with “a potential to impact their country and the world”.

My supervisors are Prof. Simon Stanworth and Dr Nicola Curry at the RDM and Dr Richard Siviter at Oxford University Hospitals’ Neuro Critical Care Unit. My research is funded by NHS Blood and Transplant and I hold project grants from the British Journal of Anaesthesia, Brain Research UK and the Oxfordshire Hospitals Charity. We collaborate closely with the University of Warwick Clinical Trials Unit, Oxford’s Weatherall Institute of Molecular Medicine, the University of Aalborg (Denmark) and the Centre for Neurotrauma at the University of Cambridge.