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Antje Grotz

MSc; BSc

DPhil Student

I'm from Germany and graduated with a BSc in Integrated Life Sciences - Biology, Biomathematics, Biophysics in 2015 from the University of Erlangen-Nuremberg. During my undergraduate studies, I carried out summer internships abroad at the University of Costa Rica and the University of British Columbia as part of the RISE worldwide programme (German Academic Exchange Service) and looked at inhibiting productive dengue virus infection by a serpin-based antiviral strategy targeted at host cell proprotein convertases. In 2016, I graduated with a MSc in Cell and Gene Therapy from University College London and worked on an adeno-associated viral vector based gene therapy as a novel treatment for chronic kidney disease.  Since then I have started a DPhil at the Oxford Centre for Diabetes, Endocrinology & Metabolism, supervised by Prof. Anna Gloyn. I am working on identifying the genes mediating type 2 diabetes risk at genome-wide association studies loci using high throughput methodologies in human beta-cell models to simultaneously genetically manipulate thousands of genes followed by characterisation of the impact of loss of their function on insulin production. In my free time, I love travelling and being involved in college life (St Anne's college), currently holding the position as social secretary.


Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Dwivedi OP, Lehtovirta M, Hastoy B et al, Nature Genetics (2019)

A CRISPR/Cas9 genome editing pipeline in the EndoC-bH1 cell line to study genes implicated in beta cell function.

Grotz AK et al, Wellcome Open Res (2019), 4(150)

Prioritising Causal Genes at Type 2 Diabetes Risk Loci.

Grotz AK et al, Curr Diab Rep (2017), 17