Novo Nordisk Postdoctoral Research Fellow (2016-2019)
- Project: Investigating lipid metabolism in islet a-cells and gut L-cells, as a nutrient sensing mechanism controlling hormone secretion
Anna was awarded the Novo Nordisk Postdoctoral Fellowship in 2016, working with Dr James Cantley and Professor Heidi de Wet in DPAG. During her fellowship, she broadened the understanding of the connection between nutritional status of the pancreatic α and gut enteroendocrine L-cells and their ability to respond to metabolic stimuli. This work combined the establishment of genetically and pharmacologically modified organisms, primary ex vivo models and cell lines. It uncovered the central role played by Acetyl-CoA-Carboxylase 1 (ACC1) in the regulation of endocrine cell growth and hormone secretion.
Following her fellowship, Anna joined the Novo Nordisk Research Centre Oxford (NNRCO) as a Post-Doctoral Research Scientist in the Department of Discovery Biology and Pharmacology. She has recently accepted a permanent position at NNRCO as a Senior Research Scientist. In her new role, Anna is pursuing further her long-standing interest in the multi-organ pathophysiology of metabolic diseases. She is leading the development of high-throughput screening platforms for unbiased target identification in the liver.
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion Veprik A. et al (2022), Nature Commun Biol
Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1. Cyranka M. et al, (2019), Obesity
GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states. Veprik A. et al, (2016), FASEB J
The role of lycopene and its derivatives in the regulation of transcription systems: implications for cancer prevention. Sharoni Y. et al, (2012), Am J Clin Nutr
Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells. Veprik A. et al, (2012), Am J Physiol Endocrinol Metab
GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins. Bahar Halpern K. et al, (2012), J Biol Chem
Carotenoids and apocarotenoids in cellular signaling related to cancer: a review. Sharoni Y. et al, (2012), Mol Nutr Food Res