Novo Nordisk Postdoctoral Research Fellow (2016-2019)
- Project: Investigating lipid metabolism in islet a-cells and gut L-cells, as a nutrient sensing mechanism controlling hormone secretion
Anna was awarded a Novo Nordisk Postdoctoral Fellowship in 2016, working with Dr James Cantley and Professor Heidi de Wet in DPAG. During her fellowship, she broadened the understanding of the connection between nutritional status of the pancreatic α and gut L-cells and their ability to respond to metabolic stimuli. She focused on the central role that Acetyl-CoA-Carboxylase 1 (ACC1) plays in the regulation of endocrine cell growth and hormone secretion. This work combined genetic inhibition in a whole organism and ex vivo models together with transient pharmacological inhibition in ex vivo and in vitro models.
Following her fellowship, Anna joined the Novo Nordisk Research Centre Oxford (NNRCO) as a Post-Doctoral Research Scientist in the Department of Discovery Biology and Pharmacology. In her new role, she will continue to pursue her long standing interest in the pathophysiology of diabetes and its complications.
Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells. Veprik A. et al, (2012), Am J Physiol Endocrinol Metab, 303, E815 - E824