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Angelyn Bethel


Associate Professor of Diabetes and Endocrinology

  • Deputy Director, Diabetes Trials Unit

Dr M. Angelyn Bethel is Assistant Professor of Diabetes and Endocrinology at the University of Oxford and leads the mega-trials programme at the Diabetes Trials Unit (DTU), providing clinical and strategic oversight for ongoing multicenter cardiovascular outcomes trials in diabetes.  Dr Bethel is the primary investigator for GLINT, has served as the Academic Clinical Lead for the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS), the EXenatide Study of Cardiovascular Event Lowering (EXSCEL), the Acarbose Cardiovascular Evaluation (ACE), and has worked closely with the Translational Research Group at DTU, serving as a primary investigator and clinical advisor for a wide range of early phase clinical studies.


Dr Bethel completed her internship, internal medicine residency, and fellowship in Endocrinology, Metabolism, and Nutrition at Duke University Medical Center, Durham, NC, USA.  After joining the faculty, she maintained joint appointments in the Division of Endocrinology and at the Duke Clinical Research Institute (DCRI) where she received her early training in the design and conduct of large-scale clinical trials.  Dr Bethel undertook a secondment to the DTU in 2008 to assist in the analysis of the UKPDS-Post Trial Monitoring dataset, culminating in the publication of two articles in the New England Journal of Medicine describing the legacy-effect of early and intensive glucose and blood pressure control.


Dr Bethel also maintains an active clinical practice.  She is GMC registered and serves as an Honorary Consultant Physician to the Oxford University Hospitals NHS Trust.  She devotes her free time to furthering her classical vocal training, triathlons, and spending time with her family.

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