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Andrew King

BA, BMBCh, MRCP, FRCPath


DPhil Student

I am a haematology registrar training in the Oxford Deanery and a DPhil student in Professor Higgs' laboratory.  My project is focused on understanding how an embryonic globin, called zeta-globin, is silenced using both mouse and human tissue.  Zeta-globin is an unusual example of a gene that lies within an active compartment adjacent to a strong enhancer cluster, yet is normally completely silenced in definitive erythroid cells.  How it is silenced is therefore an interesting question from a gene regulation perspective.  Understanding the mechanism underlying silencing may also lead to new therapies for a condition called alpha-thalassaemia, where too little alpha-globin is produced, usually due to gene deletions. In such scenarios, reactivated zeta-globin could substitute for the missing alpha-globin.  I attended medical school at the University of Oxford and then completed general medical training in the Thames Valley Region.  I began working as a haematology registrar in 2011.

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Recent Publications

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