Andrea van Dam
BSc; MSc; PhD
Novo Nordisk Postdoctoral Research Fellow
I was awarded a Novo Nordisk Postdoctoral Research Fellowship starting in 2017, which aims to investigate the role of Hedgehog signalling in adipose tissue biology within the lab of Dr Costas Christodoulides and Professor Fredrik Karpe at the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM). I am using human genetic and physiological approaches, accompanied by studies in cellular models to better understand the mechanisms by which low frequency and common genetic variants in Hedgehog pathway genes modulate adipose tissue biology and thereby susceptibility to obesity and insulin resistance.
I studied a bachelor’s and a master’s degree in Biomedical Sciences at the University of Utrecht (The Netherlands), from which I graduated in 2013. Following my studies, I undertook a PhD on the role of inflammation in adipose tissue and lipid metabolism at the Leiden University Medical Centre (The Netherlands).
Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states.
Liu J. et al, (2019), Biochim Biophys Acta Mol Cell Biol Lipids, 1864
Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice.
Kuipers EN. et al, (2018), Int J Mol Sci, 19
‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat
Schilperoort M. et al, (2018), EMBO Molecular Medicine, 10
IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement
van Dam AD. et al, (2018), International Journal of Obesity, 42, 260 - 269
South Asian men have lower expression of IFN signalling genes in white adipose tissue and skeletal muscle compared with white men
van Dam AD. et al, (2017), Diabetologia, 60, 2525 - 2528