Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG. Castro-Dopico et al. (2019) find a profound induction of anti-commensal IgG in the colonic mucosa of UC patients and outline a pathway whereby FcγR activation by IgG triggers IL-1β production, type 17 immunity, and the exacerbation of inflammation.
Journal article
2019-04-16T00:00:00+00:00
50
1029 - 1031
2
Colitis, Colitis, Ulcerative, Colon, Genome-Wide Association Study, Humans, Immunoglobulin G, Inflammation, Intestinal Mucosa