BSc, MSc, PhD
I am a developmental and stem cell biologist at the MRC Molecular Haematology Unit (MHU) in the Weatherall Institute of Molecular Medicine. I received my PhD degree in Molecular Biology (Developmental Biology) from King’s College London in 2001 and, after undertaking a postdoctoral position in the University of Nottingham, I joined the MRC MHU.
I am interested in the development of the haematopoietic system, in particular how haematopoietic stem cells (HSCs) are created during embryogenesis. I have established Xenopus as a unique model for the study of the ontogeny of this tissue stem cells. Using this model organism, I made the all-important demonstration that adult and embryonic blood have distinct origins and are differentially programmed.
I have also identified and characterised the niches where the precursors for HSCs reside temporarily and demonstrated that signalling pathways are recurrently used during HSC programming, particularly that the growth factor VEGFA plays several distinct roles.
I am currently establishing the gene regulatory networks controlling the programming of HSCs in the embryo and I am establishing collaborations aiming to applying this information for the establishment of protocols for the in vitro differentiation of HSCs from pluripotent stem cells.
The embryonic origins and genetic programming of emerging haematopoietic stem cells.
Ciau-Uitz A. and Patient R., (2016), FEBS Lett, 590, 4002 - 4015
Ontogeny of the Hematopoietic System
Ciau-Uitz R. et al, (2016), Encyclopedia of Immunobiology - Myeloid and B Cell Development
Developmental hematopoiesis: ontogeny, genetic programming and conservation.
Ciau-Uitz A. et al, (2014), Exp Hematol, 42, 669 - 683
ETS transcription factors in hematopoietic stem cell development
Ciau-Uitz A. et al, (2013), Blood Cells, Molecules, and Diseases, 51, 248 - 255
ETS transcription factors in hematopoietic stem cell development.
Ciau-Uitz A. et al, (2013), Blood Cells Mol Dis, 51, 248 - 255