PhD, BSc (Hons)
My research focuses on vascular mechanotransduction. This means studying the effect of mechanical forces, caused by blood flow, on the cardiovascular system. Mechanical forces are critical in regulating cellular processes in development, health and disease. My work is specifically focused on understanding how mechanical force affects the mechanisms and machinery that are used to make new proteins. This is important to understand how cells sensing changes in blood flow can translate to differences or modifications in cell structure and behaviour. Through gaining a better understanding of how cells respond to mechanical force we hope to develop new methods of treating numerous cardiovascular diseases.
Temperature-induced cardiac remodelling in fish.
Keen AN. et al, (2017), The Journal of experimental biology, 220, 147 - 160
Kinematics and energetics of swimming performance during acute warming in brown trout Salmo trutta.
Lea JMD. et al, (2016), Journal of fish biology, 88, 403 - 417
The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle.
Keen AN. et al, (2015), Frontiers in physiology, 6
Rainbow trout provide the first experimental evidence for adherence to a distinct Strouhal number during animal oscillatory propulsion.
Nudds RL. et al, (2014), The Journal of experimental biology, 217, 2244 - 2249