{ "items": [ "\n\n
\n \n\n \n \n \n \n MRC Molecular Haematology Unit\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n\n \n\n\n
\n \n \n \n\n \n \n\n \n\n \n \n \n \n Cardiovascular Clinical Research Facility\n \n \n \n \n Division of Cardiovascular Medicine\n \n \n \n \n Oxford Centre for Clinical Magnetic Resonance Research\n \n \n\n \n\n\n
\n \n \n \nOur expertise is in clinical trials, whereby we aim to discover novel treatments for improving the health of patients with cardiac diseases. \r\n\r\nWe use cardiovascular magnetic resonance imaging (CMR) and spectroscopy techniques to improve our understanding of myocardial metabolism and function, and for early detection of cardiac abnormalities in cardiomyopathy, heart failure, valve disease and diabetes. We use cardiopulmonary exercise test to understand cardiovascular exercise physiology, by studying how oxygen and other nutrients are used by the heart during exercise. \r\n\r\nWe work closely with multidisciplinary research teams including MR physicists, biomedical engineers and other cardiac imaging experts in the UK and elsewhere in the world.
\n \n\n \n \n\n \n\n \n \n \n \n Nuffield Division of Clinical Laboratory Sciences\n \n \n\n \n\n\n
\n \n \n \nWe are a computational biology research group using genomic and functional genomic data to study transcriptional regulation in neuroscience.
\n \n\n \n \n\n \n\n \n \n \n \n Cardiovascular Clinical Research Facility\n \n \n \n \n Division of Cardiovascular Medicine\n \n \n \n \n Oxford Centre for Clinical Magnetic Resonance Research\n \n \n\n \n\n\n
\n \n \n \nOur group focuses on understanding how alterations to early human development affect long-term disease risk and how to reduce risk through nutritional and lifestyle interventions. Disruptions to normal development, including exposure to pregnancy complications such as being born preterm, are risk factors for early heart failure, stroke and cardiovascular events. To study early developmental changes, we use multi-modality imaging, activity monitoring, questionnaire data and birth records, as well as blood sample collection to study cellular pathways in fetal through to young adult human cohorts.
\n \n\n \n \nWe work on circadian rhythms, and nuclear receptors applied to both inflammation and energy metabolism. Our models range from cells to human populations.
\n \n\n \n \n\n \n\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n \n \n Nuffield Division of Clinical Laboratory Sciences\n \n \n\n \n\n\n
\n \n \n \nWe focus on systems level \u201cbig picture\u201d approaches to understand gene regulation and build gene regulatory networks during development and disease in zebrafish, chick, lamprey and human models.
\n \n\n \n \nResearch in the Jacobsen group is focused at unravelling normal and malignant hematopoietic stem and progenitor cell biology at the single cell level.
\n \n\n \n \n\n \n\n \n \n \n \n Investigative Medicine Division\n \n \n \n \n MRC Translational Immune Discovery Unit\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n\n \n\n\n
\n \n \n \n\n \n \n\n \n\n \n \n \n \n Investigative Medicine Division\n \n \n \n \n MRC Translational Immune Discovery Unit\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n\n \n\n\n
\n \n \n \nWe focus on the mechanisms controlling the migration of leucocytes and tumour cells via lymph in health and disease.
\n \n\n \n \nWe aim to further improve the clinical value of Cardiovascular Magnetic Resonance with application of advanced image analysis techniques.
\n \n\n \n \n\n \n\n \n \n \n \n MRC Molecular Haematology Unit\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n \n \n Nuffield Division of Clinical Laboratory Sciences\n \n \n\n \n\n\n
\n \n \n \nWe study the embryonic origins of blood stem cells with the aim to inform the generation of these cells in culture, and ultimate produce clinically relevant blood stem cells for therapeutic purposes.
\n \n\n \n \n\n \n\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n \n \n Nuffield Division of Clinical Laboratory Sciences\n \n \n\n \n\n\n
\n \n \n \nWe use state-of-the-art laboratory and computational approaches to understand how mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases.
\n \n\n \n \n\n \n\n \n \n \n \n Investigative Medicine Division\n \n \n \n \n MRC Translational Immune Discovery Unit\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n\n \n\n\n
\n \n \n \nWe are interested in how lymphocytes decide to mount immune responses against, for example, tumours. This involves trying to understanding how leukocyte receptors, such as the T-cell receptor and immune checkpoints, are triggered.
\n \n\n \n \n\n \n\n \n \n \n \n MRC Molecular Haematology Unit\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n \n \n Nuffield Division of Clinical Laboratory Sciences\n \n \n\n \n\n\n
\n \n \n \nThe Haematopoietic Stem Cell Biology (HSCB) Laboratory is focused on understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies. Our overarching aim is to improve the management of myeloproliferative neoplasms and related conditions through better monitoring and therapeutic targeting of malignant stem cell populations.
\n \n\n \n \n\n \n\n \n \n \n \n Division of Cardiovascular Medicine\n \n \n \n \n Oxford Centre for Clinical Magnetic Resonance Research\n \n \n\n \n\n\n
\n \n \n \nOCMR uses sophisticated cardiac MR imaging and spectroscopy methods to phenotype cardiovascular disease \u2013 in small-scale proof-of-principle studies, large-scale multicentre clinical trials and ultra-large scale population imaging programmes. As well as running their own research programmes, OCMR serves as a collaboration partner to any group wanting to strengthen their clinical research with state of the art non-invasive phenotyping tools.
\n \n\n \n \n\n \n\n \n \n \n \n MRC Molecular Haematology Unit\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n \n \n Nuffield Division of Clinical Laboratory Sciences\n \n \n\n \n\n\n
\n \n \n \nWe aim to understand the fundamental biological processes underlying normal and malignant haematopoiesis and translate this to improve patient outcomes through new rational therapies.
\n \n\n \n \n\n \n\n \n \n \n \n Division of Cardiovascular Medicine\n \n \n\n \n\n\n
\n \n \n \nDefining important functional paradigms that lead to inherited cardiomyopathies, in search of novel treatments.
\n \n\n \n \n\n \n\n \n \n \n \n Nuffield Division of Clinical Laboratory Sciences\n \n \n\n \n\n\n
\n \n \n \nWe lead colorectal cancer clinical trials, and study the basic biology of non-angiogenic and angiogenic tumours and mechanisms of vascular co-option.
\n \n\n \n \n\n \n\n \n \n \n \n MRC Molecular Haematology Unit\n \n \n \n \n MRC Weatherall Institute of Molecular Medicine\n \n \n \n \n Nuffield Division of Clinical Laboratory Sciences\n \n \n\n \n\n\n
\n \n \n \nUsing genomics, computational and synthetic biology approaches to understand how genes are regulated in health and disease.
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