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Coronary artery disease (CAD) is the commonest cause of death. A recent study in Nature Genetics, reports on the largest genetic study to date assessing the impact of common variation on CAD risk. 15 new risk alleles were identified, bringing the total number of confirmed CAD susceptibility loci in individuals of European and south Asian ancestry to 45.

Contractile smooth muscle cells. © Contractile SMCs in culture: F-actin in green and alpha-SM actin in red. Permission must be obtained from Ayman Al Haj Zen (ayman.alhajzen@cardiov.ox.ac.uk) before use.