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Documents for work involving genetically modified micro-organisms

Please refer to the shared drive to access relevant forms.
Before initiating work involving genetically modified micro-organisms it is necessary to complete a risk assessment under the Genetically Modified Organisms (Contained Use) Regulations 2000.
Risk assessments are also required for the generation, breeding or use of genetically modified animals.
Some pro-forma examples to aid the completion of risk assessments are available:
  • Cloning non-harmful mammalian genes into standard E.coli, yeasts and cell lines using plasmid/phage vectors.
  • Construction and use of a murine retrovirus vector expressing a non-harmful mammalian gene.
  • Construction and use of a replication-defective recombinant adenovirus vector expressing a non-harmful mammalian gene.
More complex genetic modification research may require direct notification of the HSE. In this instance a higher level of detail is required.  In this instance alteration to the  containment measure tables are required.
Construction and use of a more complex recombinant adenovirus vector.
 
Additional Guidance
Appropriate containment levels for mammalian cell cultures - further advice can be obtained from the Departmental Biological Safety Officer or the University Biological Safety Officer.
Revised  20th June 2011