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Scientific Organising Committee

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Anna Gloyn (Oxford, UK)


On behalf of the EASD Islet Study Group & the Beta-Cell Workshop I would like to welcome you to the 3rd Joint meeting of our societies.   The ethos of the meeting is to bring together basic and clinical scientists from all over the world working on all aspects of the beta-cell (and other islet cells) from their birth to their demise.    It is an opportunity to hear from the Rising Stars and outstanding experts in the field and to provide plenty of opportunities for scientific discussion and networking.

Following the scientific extravaganzas in Jerusalem (2015) hosted by Professors Yuval Dor & Ben Glaser and then in Dresden (2017) by Professor Michele Solimena the bar has been set very high for delivering fantastic islet biology coupled with superb cultural and social programmes.

For Islets in Oxford 2019 we have lined up an incredible list of international speakers who I am certain will delight us with a smorgasbord of islet biology accompanied by plenty of opportunities for networking washed down with an opportunity to experience life in an Oxford College, including the full Formal Hall dinning experience.    To ensure that we are culturally nourished there will be a visit to Oxford's celebrated Ashmolean Museum.

The local organising team and I look forward to welcoming you to Oxford!

Anna Gloyn

Chair of the Scientific  & Local Organising Committees

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Lena Eliasson (MALMO, Sweden)

http://research.med.lu.se/islet-cell-exocytosis

http://portal.research.lu.se/portal/en/persons/lena-eliasson(ce323f22-e03e-40cf-a37a-8ad9dd035fdd).html     

Lena Eliasson is appointed Professor in Experimental Diabetes Research at Lund University and she is part of Lund University Diabetes Centre (LUDC). Her research aims to understand cellular mechanisms underlying impaired islet hormone secretion contributing to the pathogenesis of diabetes. The focus is on single cell physiology involving studies of ion-channels, exocytosis and miRNA networks important in the regulation of islet cell secretion.

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Lori Sussel (DENVER, USA)

www.Sussellab.org  

Dr. Lori Sussel is the Director of Basic and Translational Research at the Barbara Davis Center for Diabetes at the University of Colorado. Dr. Sussel’s research program focuses on pancreatic islet cell development and function, which has contributed to the understanding of the islet dysfunction that occurs during the course of diabetes. Most recently, she has made exciting discoveries in the new field of long non-coding RNAs and their regulation of islet development and function. 

 

EASD - Islet Study Group

The EASD Islet Study Group is a study group of the European Association for the Study of Diabetes (EASD) which focuses on research into islet biology in diabetes

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CHAIRPERSON 

The EASD Islet Study Group arose from discussions of participants of the islet meeting held at Coleraine 15-18 September 1991. Since this time, the Group has held meetings annually in close association with the main EASD Congress. Approximately 120 participants attend each meeting, which is of 2-days duration.The current chair is Dame Professor Francis Ashcroft FRS FMedSci (Oxford, UK).

Details on the study group can be found here

https://www.dpag.ox.ac.uk/team/frances-ashcroft

 

 

BETA -CELL WORKSHOP

The Beta-Cell workshop was started spontaneously in the 1990's by a number of rising stars in the field including Ole Madsen (then at Novo Nordisk) and Susan Bonner-Weir.  Since the first meeting a recognized person in the field has taken on the task to organize the meetings. In 2013  Susumu Seno hosted the legendary meeting in in Kobe Japan.  In constrast to the EASD-ISG, the BCW is not affiliated to any formal society and the membership has a more North-American flavour. 

 

The two meetings first came together in 2015 when Yuval Dor and Ben Glaser hosted the first Joint Meeting in Jerusaleum.  The baton was handed at that meeting to Michele Solimena (Dresden) for the 2017 meeting and in Dresden to Anna Gloyn for IsletsinOx2019.

Who will take the batton next and where will the meeting be in 2021?  

LOCAL ORGANIsING COMMITTEE - ISLETSINOX2019@OCDEM.OX.AC.UK

 

Dr. Marco Pontecorvi  

BRC Project Manager - OCDEM

marco.pontecorvi@ocdem.ox.ac.uk

0044(0)1865 227441

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Skirmante TAMELYTE

McCarthy-Gloyn PA - OCDEM

mccarthygloynpa@ocdem.ox.ac.uk

0044 (0)1865 857298

 

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Jakob Knudsen

https://www.rdm.ox.ac.uk/people/jakob-knudsen

Jakob has a background in cellular biology and physiology from the University of Copenhagen where he also obtained his PhD, studying the role of skeletal muscle as an endocrine organ during exercise. He came to Oxford in September 2015 to start a Novo Nordisk Postdoctoral Research Fellowship with Professor Patrik Rorsman at the Oxford Centre for Diabetes, Endocrinology & Metabolism. His current research is focused on how regulation of glucagon secretion contributes to the development of diabetes. His main interest is regulation of α-cell metabolism and how perturbations of α-cell metabolism affect glucagon secretion and whole-body metabolism.

 

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nicole krentz

https://www.med.ubc.ca/nicole-krentz/

Nicole Krentz is a postdoctoral research fellow at the Wellcome Centre for Human Genetics at the University of Oxford and the Robert Turner Research Associate at Green Templeton College. In 2018, Nicole completed her PhD at the University of British Columbia under the supervision of Francis Lynn. Her PhD research focused on pancreas development and endocrine cell genesis using mouse embryos and human embryonic stem cell differentiation as models. In collaboration with Michael German's lab at the UCSF, Nicole discovered that the cell cycle regulates endocrine cell development by phosphorylating the transcription factor Neurog3. In 2018 Nicole moved to Oxford and joined Anna Gloyn's group where she is now investigating the role of diabetes associated genes in pancreas development using genome-editing inhuman induced pluripotent stem cell models.

 

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Vibe Nylander

https://www.rdm.ox.ac.uk/people/vibe-nylander

Vibe holds a MSc and PhD from the University of Copenhagen, where she studied the metabolic consequences of total body irradiation. She joined Anna Gloyn’s laboratory at the University of Oxford as a postdoctoral researcher in 2016. Vibe’s research revolves around transcriptional control, and how genetic risks variants and environmental stimuli alters the transcriptional landscape and contributes to T2D risk. Vibe works on protein-protein interaction networks and chromatin interactions of T2D GWAS loci in β-cell.

 

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Grace Yu

https://www.rdm.ox.ac.uk/people/zhuo-yu

Grace Yu is a postdoctoral scientist in Professor Anna Gloyn and Mark McCarthy's research group at the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM). She is also an Associate Research Fellow at Harbin Medical University, China. Her current research focuses on trying to understand the molecular mechanisms by which coding and non-coding changes in genomic sequences affect gene regulation and protein function in Type II Diabetes. A major component of her research includes using genetically modified animal models to study genetic variations identified in large human genome-wide associations for the risk of Type II Diabetes. By investigating genetic variations more closely in mice, this allows her to discover more about the basic physiology and biology, this may ultimately be translatable for therapeutic benefit.

 

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Benoit Hastoy

https://www.rdm.ox.ac.uk/people/benoit-hastoy

Benoit obtained his MSc and PhD from the University of Bordeaux where he worked on the mechanisms of membrane fusion in exocytosis under the supervision of Professor Lang. In 2012, he joined the University of Oxford as postdoctoral researcher in Professor Patrik Rorsman's team at OCDEM where he learnt electrophysiology and worked on exocytosis in T2D context. In 2015, he joined Professors Anna Gloyn's and Mark McCarthy's teams to investigate the cellular physiology that underlies genetic predisposition for diabetes by using electrophysiology and imaging techniques. Benoit is also involved in the characterisation of human beta cell models such as the human beta cell lines EndoC-bH1/-bH2 and the beta-like cells derived from iPSCs which are becoming essential tools to clarify the effect of T2D risk variants and beta cells dysfunctions.

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Kerry McLaughlin 

https://www.rdm.ox.ac.uk/people/kerry-mclaughlin

Dr Kerry McLaughlin joined the Oxford Centre for Diabetes, Endocrinology & Metabolism (OCDEM) as a JDRF-funded Research Fellow in 2016. Dr McLaughlin's research interests are centred on the early development of autoimmunity in type 1 diabetes and the factors triggering progression to clinical disease. Previously, she was part of the team that identified a protein called tetraspanin-7 as a major target if the immune response in type 1 diabetes. Her current work aims to characterise the immune response to tetraspanin-7 and to determine the role of this protein in the insulin-producing beta cell.

 

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Linford Briant

https://www.rdm.ox.ac.uk/people/linford-briant

To some, Linford Briant is a mathematician posing as a biologist; to others, he is a biologist posing as a mathematician. His interests lie in understanding alpha-cell physiology in health and disease. However, he has quickly realized that he should restrict his interests to understanding alpha-cells under healthy conditions, because they are a very peculiar (and fascinating) cell type!

 

 

 

HISTORY OF THE MEETING

Meeting 2017 (Germany)