Oxford Centre for Diabetes, Endocrinology and Metabolism

OCDEM is a pioneering centre that combines clinical care, research and education in diabetes, endocrine and metabolic diseases. By promoting world-class research, we aim to enhance understanding of these diseases and to accelerate the search for new treatments and cures.

Head of OCDEM

David Ray

Professor of Endocrinology, Head of OCDEM, and Co-Director Sir Jules Thorn Sleep and Circadian Neuroscience Institute

david.ray@ocdem.ox.ac.uk

History

Read about the beginnings of our centre.

Find out more

Latest publications

β-cell Gɑs signaling is critical for physiological and pharmacological enhancement of insulin secretion.
Journal article

Capozzi ME. et al, (2025), J Clin Invest
The impact of estrogen deficiency on liver metabolism; implications for hormone replacement therapy
Journal article

Dong J. et al, (2025), Endocrine Reviews
REnformer, a single-cell ATAC-seq predicting model to investigate open chromatin sites
Preprint

Riva SG. et al, (2025)
Dissecting metabolic dysfunction- and alcohol-associated liver disease (MetALD) using proteomic and metabolomic profiles.
Journal article

Liu J. et al, (2025), J Hepatol

Patient undergoing a DEXA scan

OCDEM is one of the largest dedicated research centres in diabetes, endocrinology and metabolism in Europe. Led by Professor David Ray, our work spans the spectrum of basic, translational and patient-orientated research. We are closely integrated with excellent clinical care for patients with diabetes, metabolic and endocrine conditions.

Areas of strength

Type 2 diabetes including genomics, islet biology and function, novel therapeutics and large-scale clinical trials providing evidence for best practise
Human integrative metabolic physiology
Endocrine disorders such as glucocorticoid action, pituitary tumours and calcium homeostasis