We apply and optimize advanced optical microscopy techniques, such as super-resolution STED microscopy, to decipher molecular dynamics in an unprecedented way. Our main focus is molecular plasma membrane organization, especially following immune responses.
The main research interests of our laboratory are focused on the application and development of ultra-sensitive, live-cell fluorescence microscopy techniques. These include super-resolution microscopy or nanoscopy, with a spatial resolution down to the molecular level, and superior to conventional optical microscopes. These advanced microscopes are used to unravel nanoscopic changes at the molecular level in living cells, allowing us to follow cellular immune responses or virus-host interactions. We can visualise previously undetectable molecular interactions (such as protein-protein and protein-lipid interactions), which will shed new light on different molecular pathways triggered at the cell surface and intracellularly, for example during antigen presentation by dendritic cells and T cell activation.
For further information see: www.nano-immunology.org
Our lab is closely linked with the Wolfson Imaging Centre (with Christian Eggeling as scientific director), the Micron Oxford Advanced Bioimaging Unit and the groups of Marco Fritzsche (http://www.bpi-oxford.com/) and Simon Davis. We are part of the German Research Foundation (DFG) funded PerTrans Consortium on investigating peroxisomal protein import.
Medical Research Council
German Research Foundation (DFG)
EP Abraham Cephalosporin Trust Fund
John Fell OUP Research Fund
EMBO Long-Term Fellowship
Victoria Zilles - visiting scientist
Jess Dreier - visiting scientist (current position: MEMPHYS Denmark)
Fatma Betul Can - visiting scientist (current position: MSc in CRTD Dresden)
Pablo Carravilla – visiting scientists (Basque Center for Biophysics, Bilbao)
Mathias P. Clausen - postdoctoral fellow (current position: MEMPHYS Denmark)
Jorge Bernardino de la Serna - postdoctoral fellow (current position: Group Leader at STFC Harwell)
Sebastian Strauss – Master Student
Thomas Koller - Master Student (current position: Medicine in University of Cambridge)
Siebe Block – Master Student