Antoniades Group: The Oxford Translational Cardiovascular Research Group
Our group studies the interplay between adipose tissue and the cardiovascular system. Using translational approaches, we develop novel diagnostic tools for the early detection of cardiovascular diseases and risk stratification. We also work towards the discovery of new therapeutic targets for the prevention and treatment of cardiovascular diseases, in the context of obesity and diabetes.
There are three main bodies of research undertaken by our group:
Studying the interplay between adipose tissue and the cardiovascular system
Adipose tissue is now considered to be a ‘biochemical factory’ in the human body, producing a wide range of bioactive molecules, such as adipokines and adipocytokines. These molecules exert local autocrine effects, but they also have paracrine and endocrine properties, playing a critical role in cardiovascular disease pathogenesis. Our group studies the mechanisms by which different adipose tissue depots in the human body affect vascular and myocardial disease pathogenesis, with specific focus on changes in redox-sensitive inflammatory mechanisms. Read more
Translational Research in the group
Our group undertakes translational research, moving from bench to bedside and vice versa. We have established one of the world’s most extensively phenotyped cohorts of patients undergoing cardiac surgery, The Oxford Heart Vessels & Fat (ox-HVF) cohort. The cohort includes more than 1500 patients undergoing cardiac surgery, who have been extensively phenotyped preoperatively using non-invasive imaging. Read more
The Oxford Cardiovascular Computed Tomography Programme
Since 2015, the group runs the Oxford Cardiovascular Computed Tomography Programme, in partnership with the Manor Hospital and Oxford University Hospitals NHS Foundation Trust, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. The programme includes translational cardiovascular CT imaging, supported by expertise in Artificial Intelligence and machine learning. The Oxford Academic Cardiovascular CT (OXACCT) core lab operates within the programme, and provides state-of-the-art advanced cardiovascular CT image analysis services, to academic and industrial studies. Read more
- Professor Dimitris Tousoulis, University of Athens, Greece
- Prof David Lefer, LSU School of Medicine, New Orleans, USA
- Prof Alison Noble, University of Oxford, UK
- Prof Keith M Channon, University of Oxford, UK
- Dr Milind Desai MD, Cleveland Clinic, USA
- Professor Pál Maurovich-Horvat MD, MPH, PhD, Semmelweis University, Hungary
- Prof Stephan Achenbach, University of Erlangen, Germany
- Podcast: the Secret of FRET imaging: the theory (part 1)
- Podcast: Running a FRET experiment in practice (part 2)
Clinical studies and trials
Our research group is conducting several clinical trials. These include:
- Vascular Bypass
- Art Vascular
These studies form part of the Oxford Heart Vessels and Fat (ox-HVF) cohort, which currently includes more than 1500 subjects, followed up prospectively for clinical events until 2030.
You can also find more information about our site in www.oxhvf.com.