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Our group exploits advances in complex trait genetics and functional genomics to discover novel susceptibility genes for coronary artery disease (CAD). We have set up a consortium called PROCARDIS, which is involved in performing genome-wide association analysis, next generation sequencing and measurement of novel intermediate phenotypes to yield biomarkers for CAD risk and quantitative traits for genetic analysis.

Procardis 1

CAD is the main cause of death and disability worldwide and represents a typical common complex disease with both genetic and environmental factors. In PROCARDIS, we collaborate with international scientists to discover regions of genome associated with CAD (eg:  CARDIoGRAMplusC4D consortium, Exome Consortia); understand the genetics of intermediate phenotypes (eg: blood pressure, lipids, Lp(a), diabetes, etc) and interactions with environment (eg: gender, BMI, smoking, physical activity, etc). We have incorporated UK Biobank in our discovery effort to understand the genetics of disease progression in the context of a prospective cohort. We have an active high throughput screen program prioritizing downstream functional work to investigate the contribution of CAD associated genes to disease pathophysiology.

Our team

Selected publications

Collaborations

  • Keith Channon

    Field Marshal Earl Alexander Professor of Cardiovascular Medicine

  • Hugh Watkins

    Radcliffe Professor of Medicine and Head of Department

  • Mark McCarthy

    Robert Turner Professor of Diabetic Medicine

Related research themes