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BACKGROUND: Left ventricular (LV) hypertrophy in aortic stenosis (AS) is characterized by reduced myocardial perfusion reserve due to coronary microvascular dysfunction. However, whether this hypoperfusion leads to tissue deoxygenation is unknown. We aimed to assess myocardial oxygenation in severe AS without obstructive coronary artery disease, and to investigate its association with myocardial energetics and function. METHODS: Twenty-eight patients with isolated severe AS and 15 controls underwent cardiovascular magnetic resonance (CMR) for assessment of perfusion (myocardial perfusion reserve index-MPRI) and oxygenation (blood-oxygen level dependent-BOLD signal intensity-SI change) during adenosine stress. LV circumferential strain and phosphocreatine/adenosine triphosphate (PCr/ATP) ratios were assessed using tagging CMR and 31P MR spectroscopy, respectively. RESULTS: AS patients had reduced MPRI (1.1 ± 0.3 vs. controls 1.7 ± 0.3, p

Original publication

DOI

10.1186/1532-429X-16-29

Type

Journal article

Journal

J Cardiovasc Magn Reson

Publication Date

29/04/2014

Volume

16

Keywords

Adenosine, Adenosine Triphosphate, Aged, Aortic Valve Stenosis, Biomarkers, Case-Control Studies, Coronary Circulation, Energy Metabolism, Female, Humans, Hypertrophy, Left Ventricular, Magnetic Resonance Imaging, Cine, Magnetic Resonance Spectroscopy, Male, Middle Aged, Myocardial Perfusion Imaging, Myocardium, Oxygen Consumption, Phosphocreatine, Predictive Value of Tests, Severity of Illness Index, Vasodilator Agents, Ventricular Dysfunction, Left, Ventricular Function, Left