Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND: Common variants in the FTO locus, and near MC4R locus, have been shown to have a robust association with obesity in children and adults among various ethnic groups. Associations with obesity traits among Indian adolescents have not been determined. OBJECTIVE: To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents. METHODS: Subjects for the current study were recruited from a cross-sectional cohort of 1,230 adolescents (age mean ± SD: 17.1 ± 1.9 years) from South India. RESULTS: The variant at the FTO locus was found to be associated with waist-hip ratio (WHR) but not with overall obesity in this population. No significant association was observed for obesity-traits and Mc4R variant rs17782313. CONCLUSION: The common variant of FTO (rs9939609) is associated with body fat distribution during early growth in Indian adolescents and may predispose to obesity and metabolic consequences in adulthood.

Original publication

DOI

10.1111/j.2047-6310.2013.00118.x

Type

Journal article

Journal

Pediatr Obes

Publication Date

06/2013

Volume

8

Pages

e45 - e49

Keywords

Adolescent, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Body Mass Index, Cross-Sectional Studies, Diet, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, India, Male, Obesity, Phenotype, Proteins, Receptor, Melanocortin, Type 4, Waist-Hip Ratio