Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we demonstrate that melanoma patients may bear tumor-specific CTLs expressing NK receptors. The lysis of melanoma cells by patient-derived CTLs was inhibited by the NK receptor CD94/NKG2A. Thus, tumor-specific CTL activity may be decreased through NK receptor triggering in vivo.

Original publication

DOI

10.1084/jem.190.6.775

Type

Journal article

Journal

J Exp Med

Publication Date

20/09/1999

Volume

190

Pages

775 - 782

Keywords

Antigens, CD, Antigens, Neoplasm, Cytotoxicity, Immunologic, Flow Cytometry, Humans, Killer Cells, Natural, Lectins, C-Type, Melanoma, Membrane Glycoproteins, NK Cell Lectin-Like Receptor Subfamily C, NK Cell Lectin-Like Receptor Subfamily D, Receptors, Antigen, T-Cell, Receptors, Immunologic, Receptors, Natural Killer Cell, T-Lymphocytes, Cytotoxic