Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A recombinant vaccinia has been designed to express amino acids 366-379 of influenza nucleoprotein, previously shown to be the minimal epitope recognized by a class I-restricted cytotoxic T cell clone. Target cells infected with the recombinant vaccinia virus expressing this peptide are recognized by CTL as efficiently as target cells expressing the complete nucleoprotein. The results imply the existence of a peptide transport system that constitutively passes the products of degraded proteins from the cytoplasm into a membrane-bound compartment of the cell.

Original publication

DOI

10.1084/jem.170.3.1051

Type

Journal article

Journal

J Exp Med

Publication Date

01/09/1989

Volume

170

Pages

1051 - 1056

Keywords

Animals, Cytoplasm, Epitopes, Histocompatibility Antigens Class I, Influenza A virus, Mice, Mice, Inbred CBA, Nucleoproteins, Peptide Fragments, RNA-Binding Proteins, T-Lymphocytes, Cytotoxic, Vaccinia virus, Viral Core Proteins, Viral Proteins