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Family studies, and more recent molecular genetic investigations, indicate that the Wolff-Parkinson-White (WPW) syndrome and associated preexcitation disorders can have a substantial genetic component. Because preexcitation disorders are sometimes inherited as single gene disorders, key mechanistic insights can be gained that are expected to be relevant also to the more common multifactorial forms of these traits. Potentially, such insights will inform the future management of these conditions. Where WPW is inherited as a familial trait, with or without associated cardiac defects or a systemic syndrome, there are clinical genetic ramifications that are already of practical importance.

Original publication

DOI

10.1111/j.1540-8167.2005.50139.x

Type

Journal article

Journal

J Cardiovasc Electrophysiol

Publication Date

11/2005

Volume

16

Pages

1258 - 1262

Keywords

Genetic Predisposition to Disease, Genetic Testing, Humans, Mutation, Pre-Excitation Syndromes, Wolff-Parkinson-White Syndrome